Surface-enhanced spatially offset Raman spectroscopy (SESORS)
The goal of this research is to combine surface-enhanced Raman spectroscopy (SERS) and spatially offset Raman spectroscopy (SORS) to develop a non-invasive method for spectroscopic measurements of neurochemicals through the skull.
We are using Raman excitation profiles for the discovery of biomarkers of disease. The ultimate goal of this work is to identify biomarkers specific to various diseases that are difficult to detect in early stages and build a multi-wavelength screening process for identification of these biomarkers in biofluids.
We are characterizing nano-metals that are predicted by theory to have negative real and small imaginary components of the dielectric constant for plasmonic activity in the ultraviolet spectral region. We will use these UV plasmonic materials to combine the advantages of UV-resonance Raman scattering and surface-enhanced Raman scattering (UVSERRS), for Raman interrogation of ultra-low concentrations of biological and chemical molecules.